BioLiP

Receptor Information

>6rce Chain I (length=432) Species: 1219 (Prochlorococcus marinus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ELFKEEIIHQLELHPSRLDKEKIISEAMEDGIDDFFEGIRMALDPLVTFG
VKIVPEKESEKSQNFLWEDFRKLANKLMQRELTGHAARDAILTAMESATK
EEWNGFYRRVLIKDLRCGVSEKTINKIAKKFPKYAIPIFSCPLAHDSANH
EKKMIGKKQIEIKLDGVRVLTIIRQNKVEMFSRNGKQFHNFGHIILEIEN
VLKEDPAPYDLVLDGEVMSANFQDLMKQVHRKDGKQTKDAVLHLFDLCPL
ENFQKGRWNTKQTARSLLVKKWVAKHSLLLKHIQTLEWENVDLDTIQGQK
RFVELNKSAVEGGYEGVMIKDPDGMYECKRTHSWLKAKPFIEVTLKVVSV
EEGTGRNKGRLGAILVEGEDDGYEYSLSCGSGFSDIQREEYWSKRKHLLG
QLVEIRADAKTKSKDGVAFSLRFPRFKCFRGF

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6rce Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation.
Resolution	1.946 Å
Binding residue (original residue number in PDB)	T87 H89 R120 G122 S124 K126 T127 K157 Q227 M230 K231 R235 K236 G357 T358 R360 N361 G366 A367 L381 S382 G384 T415 K416 S417 K418 S424 L425 F427
Binding residue (residue number reindexed from 1)	T83 H85 R116 G118 S120 K122 T123 K153 Q223 M226 K227 R231 K232 G353 T354 R356 N357 G362 A363 L377 S378 G380 T411 K412 S413 K414 S420 L421 F423

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

	Molecular Function
GO:0000166	nucleotide binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination

PDB	RCSB:6rce, PDBe:6rce, PDBj:6rce
PDBsum	6rce
PubMed	31312841
UniProt	A0A0A2ACP7

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Structure of PDB 6rce Chain I Binding Site BS01