Structure of PDB 6jlz Chain I Binding Site BS01

Receptor Information
>6jlz Chain I (length=430) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPKHALQAIVLSDSYNYRFRPLTLDKPRCLLPLANTPLIEYTFEFLALAG
VQEVYVFCCAHAGQIREYIEKSKWNLPSSPFSVNTIVSRESLSVGDALRE
LDSKQLITSDFILVSGDVVSNVPLNEVLKEHRKRREDDKNAIMTMVVREA
SPFHRTRARTESSVFVIDKKTSQCVHYQANERGKHYVSMDPEIFNEHEEL
EVRNDLIDCQIDICSNDVPALFTENFDYQDIRKDFVYGVLTSDLLGKKIH
CHVAKENYAARVRSLQTYDAISKDVLSRWVYPFVPDSNLLNQTFSYQRHQ
IYKEEDVVLARSCIIKARTLIGAYTKVGDASVVANTIIGRNCTIGSNCSI
DSAFLWEDVVIGDNCRIGKAILANSVKIGNNCSIEDGAIVAAGVVIGDNT
IIEKNKRLTTFESHSQGTLNDPSLVGIGGR
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain6jlz Chain I Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6jlz Structural basis for eIF2B inhibition in integrated stress response.
Resolution3.35 Å
Binding residue
(original residue number in PDB)		Y53 L301
Binding residue
(residue number reindexed from 1)		Y41 L289
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0009058 biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6jlz, PDBe:6jlz, PDBj:6jlz
PDBsum6jlz
PubMed31048492
UniProtP56287|EI2BE_SCHPO Translation initiation factor eIF2B subunit epsilon (Gene Name=tif225)

[Back to BioLiP]