Structure of PDB 6e3k Chain I Binding Site BS01

Receptor Information
>6e3k Chain I (length=213) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRPVVYQVQFKYTDSKWFTA
DIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELGALHSAWV
TMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYV
HYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVG
HLSNISCYETMAD
Ligand information
Ligand IDCYS
InChIInChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1
InChIKeyXUJNEKJLAYXESH-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CS)C(O)=O
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)S
CACTVS 3.341N[C@@H](CS)C(O)=O
ACDLabs 10.04O=C(O)C(N)CS
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)S
FormulaC3 H7 N O2 S
NameCYSTEINE
ChEMBLCHEMBL863
DrugBankDB00151
ZINCZINC000000895042
PDB chain6e3k Chain I Residue 309 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6e3k Structure of the IFN gamma receptor complex guides design of biased agonists.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		C174 P191 R193
Binding residue
(residue number reindexed from 1)		C147 P164 R166
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6e3k, PDBe:6e3k, PDBj:6e3k
PDBsum6e3k
PubMed30814731
UniProtP38484|INGR2_HUMAN Interferon gamma receptor 2 (Gene Name=IFNGR2)

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