Structure of PDB 5t5h Chain I Binding Site BS01

Receptor Information
>5t5h Chain I (length=192) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVDLTGVQKKKRVVRHHTYSTNPYIKLLIKLYKFLAQRTNSAFNKLVHQR
LLKSRSNRAPISLSRIAVCMKRKSVWLEKGKKAPIAVIVGDVLDDVRMAR
IPALRVCALRFSKSARERITGAGGECLTFDQLAMVAPTGKNTFLLRGRKS
GRESVKHFGAAGVPGSHAKPFTSNRGKERQRSSARRRAFRHK
Ligand information
>5t5h Chain A (length=1278) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacuaag
cggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaaga
gggauccaacucguugccgaaucgguucuuauaggaacuugaguuguggc
aauggugcaggaauggugaaauucaaagcaaacccguugcuacaucaugu
gaguauugagccaaagaagguguuagcccauugagccaugaaccuaagag
aguagcacugcuugggagugcagugucaagcuggcagguaugugucugcc
aaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcg
aaaguuugaaaagcacuuuggaaagagagugacauagaccugaagucgug
acaauaauggaaguaccuccauuucgccaaaaccagccucuacugagcaa
gaacgaggucaugguuuuggcggaaauggggugcccccacccgucuugaa
acacggaccaaggagucaaacagacgcgcaagggagaagauaucaguacu
ucucucguacugaaagggagauuguggugugcacacuugcccaacaccga
ccggccccggguugaguuggagugugccuguuuggacccgaaagguggug
aacuaugccugaacaaggugaagcccggggaaacucggguggaggccugu
agcgaugcugacgugcaaaucgcucgcaugauuuggguaucggagcgaaa
gacucaucgaaccaccuaguagcugguucacaucgaaguuucccucagga
uagcuggugcuugaaaaaguauugugcgguaaagcuuuaaaugugcaacu
ugccaaagcaagguauuaaggcaccaagugggccuucuucgguaagcgga
gcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuau
gggcucacgaacaauggaugacgcucaagcccaauuagugcccauuauuc
cuuugguaagggcgagaaaguguagcccuuccgauguagauguggcgugg
agguaaggacgaagcugauggcgugagccucagauggaccagccucuagu
gcagaucuugguuggcguagcaaagaucuaacggaacguuggauacugga
gcggggaaggauuucgugccaacggcacucguacacgaguuguucggaua
cugagcacaacguuacaccguuuuuaggaaaaggggcaacagagaaccug
ggauuauauuccaaaaagaaauugcaug
.......................<<<<<......<......>.......>
>>>.>.........<<....>>...<<<<<......<<.....>>....>
>>>>....<<<..<<<<<<..<<<<<<<......>>>>>.>>....>>>>
>>......<<<.<<<<<......<<<<<<<.......>>>>.<.....>.
.....>>>.<<.......((.....>>)).....>>>>>...>>>.....
....<<<<<<<........>>>>>>>......<<<<<........>>>>>
..>>>....................................<<....>>.
...............<<<......>>>.......................
.......<<<..<<<<<<.<<<<<.<<<<<<<<<<<<<<...<<.>>...
.....>>>>..>>>>>>>>>>..>>>>>>>>>>>..>>>.<<<<......
..>>>><<<<<<...<<<<<<<<.<<<<<..<<<<..<<.<<<..>>>>>
..>>>>...<<....>>........<<<<<...<<..>>....>>>>><<
<<<<<<<.>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<...<<<<<<.
....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>..
.<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.....
..>>......>>>>>>......>.>>...<<<<<....<.<<<....>>>
(><<<<<<<<<.....<<...<<<<<<<...<<<.>>>...>>>>>>><<
<<<....>>>>>...>>..>>>>>>>.>>).<<<<.<<<<<.....>>>>
>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..
<<<<....<..........))).>....>>>>.>.....>>>...>>>>>
>><<<<.<<<<<.............>>>>>>>>>....>>>>>.....<<
<<<<..........<<<..<<<....>>>.>>>........>>>>>>...
......>>>>>>..............<<<<<<<...>>>>>>>.......
.............<<<<<....<<.....>>..>>>>>....<<......
....<<.<<<<<......>>>>...........>.>>..........<<<
<.........>>....>>.>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t5h Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.
Resolution2.54 Å
Binding residue
(original residue number in PDB)
G2 Q9 K10 K11 R13 V14 V15 R16 H17 H18 Y20 S21 T22 K31 K34 F35 A43 F44 L47 K54 S55 R56 N58 S63 S65 R66 V69 C70 K72 R73 K74 W77 D92 L94 D95 D96 V97 R98 M99 R101 R111 S113 K114 S115 G140 K141 N142 T143 F144 L146 R147 R149 K150 S151 G152 R153 E154 S155 F159 H168 K170 P171 F172 T173 N175 R176 G177 R187 A189
Binding residue
(residue number reindexed from 1)
G1 Q8 K9 K10 R12 V13 V14 R15 H16 H17 Y19 S20 T21 K30 K33 F34 A42 F43 L46 K53 S54 R55 N57 S62 S64 R65 V68 C69 K71 R72 K73 W76 D91 L93 D94 D95 V96 R97 M98 R100 R110 S112 K113 S114 G139 K140 N141 T142 F143 L145 R146 R148 K149 S150 G151 R152 E153 S154 F158 H167 K169 P170 F171 T172 N174 R175 G176 R186 A188
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:5t5h, PDBe:5t5h, PDBj:5t5h
PDBsum5t5h
PubMed27791004
UniProtQ4DZP2|RL18_TRYCC Large ribosomal subunit protein eL18 (Gene Name=RPL18)

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