Structure of PDB 5ool Chain I Binding Site BS01

Receptor Information

>5ool Chain I (length=158) Species: 9606 (Homo sapiens)

SKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPGLIRLLRREIAAV
FQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSK
YQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLGGCIDDTILSRQ
GFINYSKL

Ligand information

>5ool Chain A (length=1441)

gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagca
cacccgucuauguagcaaaauagugggaagauuuauagguagaggcgaca
aaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguuc
aacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguua
guccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagag
aguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaag
aaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccuc
acacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguau
aaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugac
aauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccuca
cugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaa
aggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucua
gcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacgg
ccgcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaau
ggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugacc
ugcccgugaagaggcgggcauaacacagcaagacgagaagacccuaugga
gcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggcg
accucggagcagaacccaaccuccgagcaguacaugcuaagacuucacca
gucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguua
cccuagggauaacagcgcaauccuauucuagaguccauaucaacaauagg
guuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuau
uaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucaga
ccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaa
aggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaug
auaucaucucaacuuagauacccacacccaagaacaggguu

<<<.......<<<<...............................<....
..>...........<<.....>>.......>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>.
..<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.....
..>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>>
<<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.
<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<
<<...<..............<....<<<.........>>>....>.....
..<<<......>>>..........................>...>>>>>>
........>>>>>>...<<<<<......>>>>>.........>>>>>><.
.....<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>
......<<<...<<<<.......................>>>>.......
>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.
<<.........<......<<<<<<..<<<.........>>>...<<<<<<
.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>
>..........<...........<<<<<<.....>>>>>>.....>....
>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>....
.<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<
<<<..<<<<<.<<<<<<<<......>>>>>>>>>>>>>..<<<<.....>
>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>
>>>..>>>....>>.........<<<....>>>............>>>>.
.>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>
...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>
>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<
<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<..........
.......>>>.>>><<<<<...<<<....>>>.>>>>>......<<<...
.............>>>.........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ool Structures of the human mitochondrial ribosome in native states of assembly.
• Resolution: 3.06 Å
• Binding residue (original residue number in PDB): K31 V33 T34 R35 R38 H41 Q43 K46 A106 V125 P127 N128 G149 H150
• Binding residue (residue number reindexed from 1): K2 V4 T5 R6 R9 H12 Q14 K17 A67 V86 P88 N89 G110 H111

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5ool, PDBe:5ool, PDBj:5ool
• PDBsum: 5ool
• PubMed: 28892042
• UniProt: Q7Z7H8|RM10_HUMAN Large ribosomal subunit protein uL10m (Gene Name=MRPL10)