Structure of PDB 5ntd Chain I Binding Site BS01

Receptor Information
>5ntd Chain I (length=519) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGT
HKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRV
VVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLP
IAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAV
ATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERG
YGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKP
ADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYR
NDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATL
TGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPE
FKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFN
SNGATGFGPALLTEYFRKL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain5ntd Chain I Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ntd Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation inTrypanosoma brucei.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D294 K301 D371 E373
Binding residue
(residue number reindexed from 1)		D292 K299 D369 E371
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) K301 R375
Catalytic site (residue number reindexed from 1) K299 R373
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ntd, PDBe:5ntd, PDBj:5ntd
PDBsum5ntd
PubMed28815215
UniProtQ385B0

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