Structure of PDB 5lf3 Chain I Binding Site BS01

Receptor Information

>5lf3 Chain I (length=204) Species: 9606 (Homo sapiens)

SIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYI
GLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFG
PYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCE
SLWEPNMDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLK
ARMD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5lf3 Chain I Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5lf3 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): V174 D177 S180
• Binding residue (residue number reindexed from 1): V174 D177 S180
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.25.1: proteasome endopeptidase complex.

Gene Ontology

Molecular Function

• GO:0005515 protein binding

Biological Process

• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0000502 proteasome complex
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005839 proteasome core complex
• GO:0019774 proteasome core complex, beta-subunit complex
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:5lf3, PDBe:5lf3, PDBj:5lf3
• PDBsum: 5lf3
• PubMed: 27493187
• UniProt: P49720|PSB3_HUMAN Proteasome subunit beta type-3 (Gene Name=PSMB3)