Structure of PDB 5lc5 Chain I Binding Site BS01
Receptor Information
>5lc5 Chain I (length=176) Species:
9913
(Bos taurus) [
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TYKYVNLREPSMDMKSVTDRAAQTLLWTELIRGLGMTLSYLFREPATINY
PFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITIEAEPRA
DGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYN
KEKLLNNGDKWEAEIAANIQADYLYR
Ligand information
Ligand ID
SF4
InChI
InChI=1S/4Fe.4S
InChIKey
LJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 2.0.7
[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385
S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
Formula
Fe4 S4
Name
IRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain
5lc5 Chain I Residue 201 [
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Receptor-Ligand Complex Structure
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PDB
5lc5
Structure of mammalian respiratory complex I.
Resolution
4.35 Å
Binding residue
(original residue number in PDB)
H65 C87 P88 C116 Y118 C119 C122
Binding residue
(residue number reindexed from 1)
H65 C87 P88 C116 Y118 C119 C122
Annotation score
1
Enzymatic activity
Enzyme Commision number
7.1.1.2
: NADH:ubiquinone reductase (H(+)-translocating).
Gene Ontology
Molecular Function
GO:0016651
oxidoreductase activity, acting on NAD(P)H
GO:0051539
4 iron, 4 sulfur cluster binding
Cellular Component
GO:0016020
membrane
View graph for
Molecular Function
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Cellular Component
External links
PDB
RCSB:5lc5
,
PDBe:5lc5
,
PDBj:5lc5
PDBsum
5lc5
PubMed
27509854
UniProt
P42028
|NDUS8_BOVIN NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (Gene Name=NDUFS8)
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