Structure of PDB 5hl7 Chain I Binding Site BS01

Receptor Information
>5hl7 Chain I (length=131) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLHELKPAEGSRKERNRVGRGVATGNGKTSGRGHKGQKARSGGGVRPGF
EGGQLPLFRRLPKRGFTNINRKEYAIVNLDQLNKFEDGTEVTPALLVESG
VVKNEKSGIKILGNGSLDKKLTVKAHKFSAS
Ligand information
>5hl7 Chain X (length=2705) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaaug
aaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuug
auccagagauuuccgaauggggaaacccagcaugaguuaugucauguuau
cgauauguauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguag
gacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaaga
ugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuuga
guggauccugaguacgacggagcacgugaaauuccgucggaaucugggag
gaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccagua
ccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccu
gaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgug
ccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcag
uaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuu
ggucguagacccgaaaccaggugaucuacccuuggucagguugaaguuca
ggcugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaac
ugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuc
cgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagca
cuguuuggacgaggguuaccgaauucagacaaacuccgaaugccaauuaa
uuuaacuugggagucagaacaugggugauaagguccguguucgaaaggga
aacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaa
ggauguggcguugcccagacaacuagcucacuagucgagugacacugcgc
cgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuug
gacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggac
auguggagcgcuuagaagugagaaugccggugugaguagcgaaagacggg
ugagaaucccguccaccgauugacuaagguuuccagaggaaggcucgucc
gcucuggguuagucggguccuaagcugaggccgacaggcguaggcgaugg
auaacagguugauauuccuguaccaccuacguaucgauggggggacgcag
uaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaggcgag
uaauccgguacucguggcugagcugugauggggagaagagagucguugau
uucacacugccgagaaaagccucuagauagaauaggugcccguaccgcaa
accgacacagguagucaagaugagaauucuaaggugagcgagcgaacucu
cguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcu
cuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacug
uuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggc
ugacgccugcccgugcuggaagguuaagaggagugguuagcugcgaagcu
acgaaucgaagccccaguaaacggcggcuaagguagcgaaauuccuuguc
ggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucuca
acgagagacucggugaaaucauaguaccugugaagaugcagguuacccgc
gacaggacggaaagaccccguggagcuuuacuguagccugauauugaaau
ucgggcuuucuaacccgcaccacuuaucguggugggagacagugucaagc
gggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcuca
aagguucccucagaaugguugaaaucauucauagaguguaaaggcauaag
ggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuu
agugauccggugguuccgcauggaagggccaucgcucaacggauaaaagc
uaccccggggauaacaggcuuaucucccccaagaguucacaucgacgggg
agguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggu
cccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguuca
gaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuu
gagaggagcuguccuuaguacgagaggaccgggauggacauaccucuggu
guaccaguugucgugccaacggcauagcuggguagcuauguguggacggg
auaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuuc
ccaacuugguuauaagaucccucaaagaugaugagguuaauagguucgag
guggaagcauggugacauguggagcugacgaauacuaaucgaucgaagac
uuaau
<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<....
..<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<
<<<<<<<<.......>>>>>>>.>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<
<<<<<<<..............<.<<<<<<<.<<<...<<<<<......>>
>>>((......<<<.....))>>>...>>>...>>>>>>>..>.....>>
>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<
..<<<<>>>>>..)))......]].>>>>>>>.]]...............
<<....>>....]].........<<<<....>>>>...............
...>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...
<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.
....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.
>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<
<.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>
>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<
<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<..
.<<<<<<<<...<......>...>>>>>>>>..>>.>.....>>>>.>>>
>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<.
.....>>>...<<<<.<<<...<<<(((.....<<<<<<...........
<<..<<<<.<<<<........<<<<......>>>>....>>>>.>>>>.>
>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>
>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>
>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<
.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>
.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>
...<<<<<........>>>>>))<<<<<....<<<...<<<<....<<<<
...<<...<......<<<...{.{...>>>...<....<<<<<.<<<<..
...........>....>>>..>>>>>.....>..............>...
.>>...>>>>.........>>>.>.>>>.....>>>>>>>>>..>>....
.<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<....<<<<
<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<
<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<
<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>
>.<<<<<..<<.<<<<<<<..<<<<..<<...<<<<<..<<.>>...>>>
>>...>>..>>>>>>>>>..>>>>...........<...........<<<
<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>
>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<
<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<.<<<<<<.<<<<.
<<.>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>.>>
..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.
..<<<<<<<...<<<<<<......>>>>>>.....<<.[.(((>>....>
>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))
]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>
>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>
>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>
>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....
<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<.
..<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<
...<<<<<<<<<<<.}.}>>>>>>..>>>>>...>>>>.>>>>>...<<<
....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>
>.<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<
<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>
>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5hl7 A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism.
Resolution3.55 Å
Binding residue
(original residue number in PDB)		L3 H4 E5 L6 K7 E10 G11 S12 R13 K14 R16 N17 R18 V19 G20 R21 G22 A24 K29 T30 S31 G32 R33 H35 K36 Q38 K39 A40 R47 P48 G49 F50 L55 P56 F58 R59 R60 L61 P62 E90 S99 S116
Binding residue
(residue number reindexed from 1)		L3 H4 E5 L6 K7 E10 G11 S12 R13 K14 R16 N17 R18 V19 G20 R21 G22 A24 K29 T30 S31 G32 R33 H35 K36 Q38 K39 A40 R47 P48 G49 F50 L55 P56 F58 R59 R60 L61 P62 E90 S99 S116
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5hl7, PDBe:5hl7, PDBj:5hl7
PDBsum5hl7
PubMed27958389
UniProtP0A0F8|RL15_STAA8 Large ribosomal subunit protein uL15 (Gene Name=rplO)

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