Structure of PDB 5h9e Chain I Binding Site BS01

Receptor Information
>5h9e Chain I (length=351) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRKS
GYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGSADA
VTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIRVNLQQGVDI
ALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFTAVDDLQEQG
SAHLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIATHVVHMLAT
EVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAKDGFLQPSIQ
AFNQYWDRVANGYGLNGAAAQFSLSDVDPITAQVKQMPTLEQLKSWVRNN
G
Ligand information
>5h9e Chain L (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auaaaccgacgguauuguucagauccuggcuugccaacaggaguuccccg
cgccagcgggg
..............................................<<<<
<....>>>>>.
Receptor-Ligand Complex Structure
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PDB5h9e Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.
Resolution3.21 Å
Binding residue
(original residue number in PDB)		N19 R20 D21 K27 S40 Q42 S43 K45 R46 R49 R165 M166 A167 K177 D179 W199 F200 T201 V203 S211 Q234 A265 K266 R268
Binding residue
(residue number reindexed from 1)		N18 R19 D20 K26 S39 Q41 S42 K44 R45 R48 R155 M156 A157 K167 D169 W189 F190 T191 V193 S201 Q224 A255 K256 R258
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0051607 defense response to virus
GO:0099048 CRISPR-cas system
Cellular Component
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5h9e, PDBe:5h9e, PDBj:5h9e
PDBsum5h9e
PubMed26863189
UniProtQ46899|CASC_ECOLI CRISPR system Cascade subunit CasC (Gene Name=casC)

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