Structure of PDB 5fur Chain I Binding Site BS01

Receptor Information
>5fur Chain I (length=912) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVR
INDLEAAFIYNELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVV
PSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMV
AVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMH
EVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAY
VEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMS
WSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVL
LHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENR
ISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGK
DIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGP
LKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVD
MDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQ
ESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTW
TGPPAMKSLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDV
HNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVN
NEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQK
NGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNM
IQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSH
DWRLRCGAVDLY
Ligand information
>5fur Chain F (length=80) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccgtaggcacgtctgctcggctcgagtgttcgatcgcgactgaggacgaa
cgcgcccccacccccttttataggcgccct
Receptor-Ligand Complex Structure
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PDB5fur Structure of Promoter-Bound TFIID and Model of Human Pre-Initiation Complex Assembly.
Resolution8.5 Å
Binding residue
(original residue number in PDB)		N542 C592
Binding residue
(residue number reindexed from 1)		N479 C529
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006282 regulation of DNA repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0014070 response to organic cyclic compound
GO:0042789 mRNA transcription by RNA polymerase II
GO:0045893 positive regulation of DNA-templated transcription
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0033276 transcription factor TFTC complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fur, PDBe:5fur, PDBj:5fur
PDBsum5fur
PubMed27007846
UniProtQ6P1X5|TAF2_HUMAN Transcription initiation factor TFIID subunit 2 (Gene Name=TAF2)

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