Structure of PDB 5flv Chain I Binding Site BS01

Receptor Information
>5flv Chain I (length=226) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRR
YKSKRQRVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVVTGLNPKTK
YILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWM
RQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADSTHVFPETAF
IAVTSYQNHKITQLKIENNPFAKGFR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5flv Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
Resolution3.005 Å
Binding residue
(original residue number in PDB)		F144 Q180 I183 W184 N187 K191 N1162 S1175 T1215 P1231 F1232 K1234 G1235
Binding residue
(residue number reindexed from 1)		F5 Q41 I44 W45 N48 K52 N163 S176 T204 P220 F221 K223 G224
Binding affinityPDBbind-CN: Kd~50nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5flv, PDBe:5flv, PDBj:5flv
PDBsum5flv
PubMed26875865
UniProtP42582;
P70326

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