Structure of PDB 5f9h Chain I Binding Site BS01

Receptor Information
>5f9h Chain I (length=644) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQ
KGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVE
NNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFN
YLDQKLGGGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIAT
VKHNLEELEQVVYKPQKFFRKVESRIDKFKYIIAQLMRDTESLAKRICKD
EFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDAL
IISEHARMKDALDYLKDFFSNVRAAFDEIEQDLTQRFEEKLQELESVSRD
PSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKL
SFLKPGILTGRGGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQ
TRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVF
REKILHIQTHEKFIRDSQKPVPDKENKKLLCRKCKALACYTADVRVIEEC
HYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKY
KTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAEM
Ligand information
>5f9h Chain J (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f9h Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		N298 Q299 I300 G326 T347 Q349 K379 Q380 H381 Q507 E510 Q511 R546 K635 T636 R637 G663 R664 T697 S698 N720 K750 F853 S854 K888
Binding residue
(residue number reindexed from 1)		N59 Q60 I61 G87 T108 Q110 K140 Q141 H142 Q255 E258 Q259 R294 K382 T383 R384 G410 R411 T421 S422 N444 K474 F574 S575 K609
Binding affinityPDBbind-CN: Kd=1.8nM
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5f9h, PDBe:5f9h, PDBj:5f9h
PDBsum5f9h
PubMed26733676
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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