Structure of PDB 5f9f Chain I Binding Site BS01 |
| >5f9f Chain I (length=674) Species: 9606 (Homo sapiens)
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PFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQ
KGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVE
NNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFN
YLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVI
ATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRI
CKDLEREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLR
KYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQE
LESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNW
IEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIA
TSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAG
VIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEK
PVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHP
KPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIA
TGVQTLYSKWKDFHFEKIPFDPAE |
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| PDB | 5f9f Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. |
| Resolution | 2.601 Å |
Binding residue
(original residue number in PDB) | N298 I300 S325 G326 T347 Q349 I350 K379 Q380 Q507 E510 Q511 R546 K635 T636 R637 T662 G663 R664 T667 N668 T697 S698 V718 N720 K750 H830 F853 K858 I875 V886 K888 |
Binding residue
(residue number reindexed from 1) | N59 I61 S86 G87 T108 Q110 I111 K140 Q141 Q261 E264 Q265 R300 K389 T390 R391 T416 G417 R418 T421 N422 T451 S452 V472 N474 K504 H582 F605 K610 I627 V638 K640 |
| Binding affinity | PDBbind-CN: Kd=38.5nM |
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| Enzyme Commision number |
3.6.4.13: RNA helicase. |
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