Structure of PDB 5f98 Chain I Binding Site BS01

Receptor Information
>5f98 Chain I (length=647) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQ
KGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVE
NNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFN
YLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVI
ATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRI
CKDLENNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSH
LRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKL
QELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALK
NWIEGNPKLSFLKPGILTDHNILIATSVADEGIDIAQCNLVILYEYVGNV
IKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTW
DEAVFREKILHIQTHEKFIRDSQPVPDKENKKLLCRKCKALACYTADVRV
IEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGI
HVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAE
Ligand information
>5f98 Chain J (length=24) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f98 Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Resolution3.28 Å
Binding residue
(original residue number in PDB)		N298 Q299 I300 S325 G326 T347 Q349 I350 K379 Q380 H381 Q507 V514 R546 K635 T636 R637 T697 S698 N720 H830 F853 K858 K861 I875 K888 W908
Binding residue
(residue number reindexed from 1)		N59 Q60 I61 S86 G87 T108 Q110 I111 K140 Q141 H142 Q263 V270 R302 K391 T392 R393 T426 S427 N449 H555 F578 K583 K586 I600 K613 W633
Binding affinityPDBbind-CN: Kd=1.7nM
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5f98, PDBe:5f98, PDBj:5f98
PDBsum5f98
PubMed26733676
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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