Structure of PDB 5epi Chain I Binding Site BS01

Receptor Information
>5epi Chain I (length=708) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKARPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLADLFD
YKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSNESSL
DEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDIDFKLGQTISRLRDISV
PAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLTWEDLRPIG
PHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKECLEKYSTL
RDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQKTNYAKWAT
GDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEMNLLSTLTSK
RALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYVLFHTSLL
NESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRGDTDVVTV
VTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCRVNGTNKIQ
MKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDRVNSPKTFS
IGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRRLLLLIQ
ALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWLGFEKEGSKV
LESVDEIM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5epi Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		T366 G367 G369 L370 T371 Y372 H506 V513 T515 R558 V559 N560 G561 T562
Binding residue
(residue number reindexed from 1)		T350 G351 G353 L354 T355 Y356 H490 V497 T499 R542 V543 N544 G545 T546
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5epi, PDBe:5epi, PDBj:5epi
PDBsum5epi
PubMed26711008
UniProtQ5V8Z9

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