Structure of PDB 4tma Chain I Binding Site BS01

Receptor Information
>4tma Chain I (length=47) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ITVNCPTCGKTVVWGEISPFRPFCSKRCQLIDLGEWAAEEKRIPSSG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4tma Chain I Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4tma Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		C9 C12 C32
Binding residue
(residue number reindexed from 1)		C5 C8 C28
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008657 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4tma, PDBe:4tma, PDBj:4tma
PDBsum4tma
PubMed24990966
UniProtP0A8H8|YACG_ECOLI DNA gyrase inhibitor YacG (Gene Name=yacG)

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