Structure of PDB 4qyz Chain I Binding Site BS01

Receptor Information

>4qyz Chain I (length=256) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MSNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRK
SGYYAQNIGEQGVDIALSGRMDGAMSIAHAITTHQVDSDIDWFTAVDDLQ
EQGSAHLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIATHVVHM
LATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAKDGFLQP
SIQAFNQYWDRVANGYGLNGAAAQFSLSDVDPITAQVKQMPTLEQLKSWV
RNNGEA

Ligand information

>4qyz Chain L (length=55) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

auaaaccgccagugauaaguggaaugccaugugggcugucgaguucccgg
ccggg

.............................................<<<<.
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Receptor-Ligand Complex Structure

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Structure summary

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PDB	4qyz Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target.
Resolution	3.0303 Å
Binding residue (original residue number in PDB)	N19 R20 D21 D22 K27 Q42 S43 K45 R46 R49 R165 D179 F200 T201 V203 A265 K266
Binding residue (residue number reindexed from 1)	N19 R20 D21 D22 K27 Q42 S43 K45 R46 R49 R70 D72 F93 T94 V96 A158 K159

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0071667	DNA/RNA hybrid binding

	Biological Process
GO:0051607	defense response to virus
GO:0099048	CRISPR-cas system

	Cellular Component
GO:0032991	protein-containing complex

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External links

PDB	RCSB:4qyz, PDBe:4qyz, PDBj:4qyz
PDBsum	4qyz
PubMed	25123481
UniProt	Q46899\|CASC_ECOLI CRISPR system Cascade subunit CasC (Gene Name=casC)

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