Structure of PDB 4gz0 Chain I Binding Site BS01

Receptor Information

>4gz0 Chain I (length=250) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAY
LKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLC
VNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFA
GDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAA
YKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL

Ligand information

>4gz0 Chain C (length=9) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ccgaattcg

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4gz0 Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.
Resolution	2.113 Å
Binding residue (original residue number in PDB)	L315 R316
Binding residue (residue number reindexed from 1)	L195 R196

Enzymatic activity

Enzyme Commision number

3.1.4.-

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity

View graph for
Molecular Function

External links

PDB	RCSB:4gz0, PDBe:4gz0, PDBj:4gz0
PDBsum	4gz0
PubMed	23104055
UniProt	Q9JJX7\|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

[Back to BioLiP]