Structure of PDB 4guo Chain I Binding Site BS01

Receptor Information

>4guo Chain I (length=198) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIK
VSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHL
IRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQ

Ligand information

>4guo Chain N (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cgggcttgcccg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4guo structure of p73 DNA binding domain complex with 12 bp DNA
Resolution	3.19 Å
Binding residue (original residue number in PDB)	S261 R293 A296 R300
Binding residue (residue number reindexed from 1)	S147 R179 A182 R186

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:4guo, PDBe:4guo, PDBj:4guo
PDBsum	4guo
PubMed
UniProt	O15350\|P73_HUMAN Tumor protein p73 (Gene Name=TP73)

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