Structure of PDB 3jcm Chain I Binding Site BS01

Receptor Information
>3jcm Chain I (length=416) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKFNPFEILPESIELFRTLALISLSETAQILPKIVDLKRILQQQEIKLLP
FFNEIIPLIKSNIKLMHNFLISLYSRRFPELSSLIPSPLQYSKVISILEN
ENYSKNESDELFFHLENKAKLTREQILVLTMSMKTSFKNKEPLDIKTRTQ
ILEANSILENLWKLQEDIGQYIASKISIIAPNVCFLVGPEIAAQLIAHAG
GVLEFSRIPSCNIASIGKNKHLSHELHTLESGVRQEGYLFASDMIQKFPV
SVHKQMLRMLCAKVSLAARVDAGQKNGDRNTVLAHKWKAELSKKARKLSE
APSISETKALPIPEDQPKKKRAGRKFRKYKEKFRLSHVRQLQNRMEFGKQ
EQTVLDSYGEEVGLGMSNTSLQQAVGATSGSRRSAGNQAKLTKVMKHRIS
EANQQADEFLISLGHN
Ligand information
>3jcm Chain D (length=45) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauacagagaucagcaguuccccugcauaaggaugaaccguguuu
.............................................
Receptor-Ligand Complex Structure
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PDB3jcm The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
Resolution3.8 Å
Binding residue
(original residue number in PDB)		K364 K366 A368 G369 R370
Binding residue
(residue number reindexed from 1)		K318 K320 A322 G323 R324
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003723 RNA binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005687 U4 snRNP
GO:0005739 mitochondrion
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
GO:0071011 precatalytic spliceosome
GO:0097526 spliceosomal tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3jcm, PDBe:3jcm, PDBj:3jcm
PDBsum3jcm
PubMed26743623
UniProtP49704|PRP31_YEAST Pre-mRNA-processing factor 31 (Gene Name=PRP31)

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