Structure of PDB 3hkz Chain I Binding Site BS01

Receptor Information
>3hkz Chain I (length=836) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KNIKGIKFGILSPDEIRKMSVTAIITPMDPRLGVIEPGQKCPTCGNTLGN
CPGHFGHIELVRPVIHVGLVKHIYEFLKATCRRCGRVKISEDEIEKYSRI
YNAIKKRWPSAARRLTEYVKKTAMKAQVCPHCNEKQYKIKLTPSDIRERL
EKIPDSDVEILGYDPTTSRPEWMILTVLPVPPITIRPSEDDLTHKLVDIV
RINERLKESIDAGAPQLIIEDLWDLLQYHVATYFDNEIPGLPPSKHRSGR
PLRTLAQRLKGKEGRFRGNLSGKRVDFSSRTVISPDPNISIDEVGVPEII
AKTLTVPERITPWNIEKLRQFVINGPDKWPGANYVIRPDGRRIDLRYVKD
RKELASTLAPGYIIERHLIDGDIVLFNRQPSLHRISMMAHRVRVLKGLTF
RLNLLVCPPYNADFDGDEMNLHVPQSEEAIAEAKEIMLVHKNIITPRYGG
PIIGAAQDYISGAYLLTVKTTLLTKEEAQQILGVADVKIDLGEPAILAPR
EYYTGKQVISAFLPKDFNFHGQANVSSGPRLCKNEDCPHDSYVVIKNGIL
LEGVFDKKAIGNQQPESILHWLIKEYSDEYGKWLMDNLFRVFIRFVELQG
FTMRLEDVSLGDDVKKEIYNEIDRAKVEVDNLIQKYKNGELEPIPGRTLE
ESLENYILDTLDKLRSTAGDIASKYLDPFNFAYVMARTGARGSVLNITQM
AAMLGQQSVRGERIKRGYMTRTLPHFKPYDISPEARGFIYSSFRTGLKPT
ELFFHAAGGREGLVDTAVRTSQSGYMQRRLINALSDLRAEYDGTVRSLYG
EVVQVAYGDDGVFPMYSAHGKTVDVNRIFERVVGWK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3hkz Chain I Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3hkz The X-ray crystal structure of RNA polymerase from Archaea.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C61 H71
Binding residue
(residue number reindexed from 1)		C44 H54
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3hkz, PDBe:3hkz, PDBj:3hkz
PDBsum3hkz
PubMed18235446
UniProtQ980R2|RPO1N_SACS2 DNA-directed RNA polymerase subunit Rpo1N (Gene Name=rpo1N)

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