Structure of PDB 3ghg Chain I Binding Site BS01
Receptor Information
>3ghg Chain I (length=394) Species:
9606
(Homo sapiens) [
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VATRDNCCILDERFGSYCPTTCGIADFLSTYQTKVDKDLQSLEDILHQVE
NKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIMKYEASIL
THDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGK
DCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGS
VDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELE
DWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSD
KFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQG
GTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTIG
Ligand information
>3ghg Chain Q (length=4) [
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GPRP
Receptor-Ligand Complex Structure
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PDB
3ghg
Crystal structure of human fibrinogen.
Resolution
2.9 Å
Binding residue
(original residue number in PDB)
F322 D330 K338 C339 H340 Y363 D364
Binding residue
(residue number reindexed from 1)
F321 D329 K337 C338 H339 Y362 D363
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005102
signaling receptor binding
GO:0005198
structural molecule activity
GO:0005201
extracellular matrix structural constituent
GO:0005515
protein binding
GO:0042802
identical protein binding
GO:0046872
metal ion binding
GO:0050839
cell adhesion molecule binding
Biological Process
GO:0007160
cell-matrix adhesion
GO:0007596
blood coagulation
GO:0009306
protein secretion
GO:0030168
platelet activation
GO:0031639
plasminogen activation
GO:0034116
positive regulation of heterotypic cell-cell adhesion
GO:0036345
platelet maturation
GO:0042730
fibrinolysis
GO:0045907
positive regulation of vasoconstriction
GO:0045921
positive regulation of exocytosis
GO:0050714
positive regulation of protein secretion
GO:0051258
protein polymerization
GO:0051592
response to calcium ion
GO:0065003
protein-containing complex assembly
GO:0070374
positive regulation of ERK1 and ERK2 cascade
GO:0070527
platelet aggregation
GO:0071347
cellular response to interleukin-1
GO:0071354
cellular response to interleukin-6
GO:0072378
blood coagulation, fibrin clot formation
GO:0090277
positive regulation of peptide hormone secretion
GO:1900026
positive regulation of substrate adhesion-dependent cell spreading
GO:1902042
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352
negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0005576
extracellular region
GO:0005577
fibrinogen complex
GO:0005615
extracellular space
GO:0005788
endoplasmic reticulum lumen
GO:0005886
plasma membrane
GO:0009897
external side of plasma membrane
GO:0009986
cell surface
GO:0031091
platelet alpha granule
GO:0031093
platelet alpha granule lumen
GO:0062023
collagen-containing extracellular matrix
GO:0070062
extracellular exosome
GO:0072562
blood microparticle
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:3ghg
,
PDBe:3ghg
,
PDBj:3ghg
PDBsum
3ghg
PubMed
19296670
UniProt
P02679
|FIBG_HUMAN Fibrinogen gamma chain (Gene Name=FGG)
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