Structure of PDB 2bl2 Chain I Binding Site BS01

Receptor Information

>2bl2 Chain I (length=156) Species: 1354 (Enterococcus hirae)

MMDYLITQNGGMVFAVLAMATATIFSGIGSAKGVGMTGEAAAALTTSQPE
KFGQALILQLLPGTQGLYGFVIAFLIFINLGSDMSVVQGLNFLGASLPIA
FTGLFSGIAQGKVAAAGIQILAKKPEHATKGIIFAAMVETYAILGFVISF
LLVLNA

Ligand information

• Ligand ID: NA
• InChI: InChI=1S/Na/q+1
• InChIKey: FKNQFGJONOIPTF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Na+]
• Formula: Na
• Name: SODIUM ION
• DrugBank: DB14516
• PDB chain: 2bl2 Chain I Residue 1157

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2bl2 Structure of the Rotor of the Vacuolar-Type Na- ATPase from Enterococcus Hirae
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): L61 P62 T64 Q65 Q110 E139
• Binding residue (residue number reindexed from 1): L61 P62 T64 Q65 Q110 E139
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.3.14: Transferred entry: 7.1.2.2.

Gene Ontology

Molecular Function

• GO:0015078 proton transmembrane transporter activity
• GO:0042802 identical protein binding
• GO:0046961 proton-transporting ATPase activity, rotational mechanism

Biological Process

• GO:0006814 sodium ion transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
• GO:0033179 proton-transporting V-type ATPase, V0 domain

External links

• PDB: RCSB:2bl2, PDBe:2bl2, PDBj:2bl2
• PDBsum: 2bl2
• PubMed: 15802565
• UniProt: P43457|NTPK_ENTHA V-type sodium ATPase subunit K (Gene Name=ntpK)