Structure of PDB 1t5e Chain I Binding Site BS01

Receptor Information
>1t5e Chain I (length=231) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEA
DYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQA
RINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVT
QPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVS
VDEGTGSVTIRAVFPNPNNELLPGMFVHAQL
Ligand information
Ligand ID3GR
InChIInChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1
InChIKeyMNQZXJOMYWMBOU-VKHMYHEASA-N
SMILES
SoftwareSMILES
CACTVS 3.385OC[C@@H](O)C=O
ACDLabs 12.01C(O)C(O)C=O
OpenEye OEToolkits 2.0.7C(C(C=O)O)O
OpenEye OEToolkits 2.0.7C([C@H](C=O)O)O
CACTVS 3.385OC[CH](O)C=O
FormulaC3 H6 O3
NameD-Glyceraldehyde;
GLYCERALDEHYDE;
(2R)-2,3-DIHYDROXYPROPANAL
ChEMBL
DrugBankDB02536
ZINCZINC000000895313
PDB chain1t5e Chain I Residue 361 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1t5e Structure of the periplasmic component of a bacterial drug efflux pump
Resolution3.0 Å
Binding residue
(original residue number in PDB)		G146 R147
Binding residue
(residue number reindexed from 1)		G118 R119
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015562 efflux transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042802 identical protein binding
Biological Process
GO:0046677 response to antibiotic
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1t5e, PDBe:1t5e, PDBj:1t5e
PDBsum1t5e
PubMed15226509
UniProtP52477|MEXA_PSEAE Multidrug resistance protein MexA (Gene Name=mexA)

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