Structure of PDB 1f9e Chain I Binding Site BS01
Receptor Information
>1f9e Chain I (length=153) Species:
9606
(Homo sapiens) [
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LDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALT
TTFEELHFEIKPHHDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKG
IIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPV
ETD
Ligand information
>1f9e Chain U (length=5) [
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tDEVD
Receptor-Ligand Complex Structure
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PDB
1f9e
Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex.
Resolution
2.9 Å
Binding residue
(original residue number in PDB)
R179 H237 C285
Binding residue
(residue number reindexed from 1)
R39 H96 C139
Enzymatic activity
Catalytic site (original residue number in PDB)
R177 D178 G238 C285
Catalytic site (residue number reindexed from 1)
R37 D38 G97 C139
Enzyme Commision number
3.4.22.61
: caspase-8.
Gene Ontology
Molecular Function
GO:0004197
cysteine-type endopeptidase activity
GO:0008234
cysteine-type peptidase activity
Biological Process
GO:0006508
proteolysis
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Molecular Function
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Biological Process
External links
PDB
RCSB:1f9e
,
PDBe:1f9e
,
PDBj:1f9e
PDBsum
1f9e
PubMed
10964557
UniProt
Q14790
|CASP8_HUMAN Caspase-8 (Gene Name=CASP8)
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