Structure of PDB 1ejl Chain I Binding Site BS01

Receptor Information
>1ejl Chain I (length=426) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1ejl Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		G281 N283 I286 V321 T322 G323 T328 K353 W357 N361 A364 E396 W399 G407
Binding residue
(residue number reindexed from 1)		G210 N212 I215 V250 T251 G252 T257 K282 W286 N290 A293 E325 W328 G336
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ejl, PDBe:1ejl, PDBj:1ejl
PDBsum1ejl
PubMed10764582
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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