Structure of PDB 6gzx Chain H4 Binding Site BS01

Receptor Information
>6gzx Chain H4 (length=138) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYER
VDVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEI
PRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW
Ligand information
>6gzx Chain A4 (length=1506) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
uggauc
....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<......<<.
......<<<..<<...........................>>>>>.....
.<<.......<<<<<<<...<<...<<..<....<<<.......<<<...
...>>>........>>>.....<<<<..<<........>>..>>>>...<
<.......>>...>..>>..>>.>>>>>>><<<..........<<<<<<<
.......>>>>>>>..........>>>..<<<<<<<<....>>>...>>>
>>.>>..<.<<............>.>>..<<<<<..>>>>>.......>>
......<<.<<<.....<<......>>...>>>>>.>.>>>>>>..<<<<
......<.<<.....>>>.....>>>>....<<<<<........<<<...
...>.>>..........>>>>>......<<<<..(....<<<<<......
...)..........>>>>>.>>>>..>>>>>>>>>...........<<((
.....<<<<...<<<.<<<<<..<<<<<<<<.........<<<<<<....
.>>>>>>.......>>>>>..>>>.>>>>>..........<...<<<<<<
<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>........
...<......>.>>>>>>>..>...........>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<.<<<<...>>>>.>>>>>...<<..))>>.....>>>>
>>.>>..........<<<<......>>>>.........))).].<.<..<
<<<<<<.....<<<<....<<<<<<<........<<........>>....
.......<<<............<......<.<............>>....
..................>........<<...<<<<.<..<.....<<<<
.<<<....>>>..<<<<......>>>>...>>>>........<<..<<.<
<....<....<.......>..>.....>>.>>..................
..........>>.......>...>.>...>>>.>>.........>>>...
....>>>>>>>......<<<.........<<...<<...<<.......>>
..>>.....>>.........>>>...........<<<<<<<........>
>>>>>>...........>>>>......<<<<<<..........>>>>>>.
...........>>>>>>>.>..>........<<...<<<<.<<<..<<.<
<<<..<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>..>>>
>.>>..>>>.>>>>....>>.........<<<<.<<<<....>>>>.>>>
>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gzx Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Resolution4.57 Å
Binding residue
(original residue number in PDB)		M1 L2 T3 D4 T11 R12 R14 N15 V19 K21 S29 R30 K56 P89 G90 R91 Y94 V97 S113 T114 S115 G130
Binding residue
(residue number reindexed from 1)		M1 L2 T3 D4 T11 R12 R14 N15 V19 K21 S29 R30 K56 P89 G90 R91 Y94 V97 S113 T114 S115 G130
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gzx, PDBe:6gzx, PDBj:6gzx
PDBsum6gzx
PubMed30301898
UniProtP0DOY9|RS8_THET8 Small ribosomal subunit protein uS8 (Gene Name=rpsH)

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