Structure of PDB 6gzz Chain H3 Binding Site BS01

Receptor Information
>6gzz Chain H3 (length=138) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYER
VDVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEI
PRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW
Ligand information
>6gzz Chain A3 (length=1506) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
uggauc
....<<<<....(((..>>>>.<<...<<<<...<<<<<<<......<<<
.<<<..<<<..<<...........................>>>>>.....
.<<.......<<<<<<<<..<<...<<<<<....<<<.....<<<<<...
...>>>>>......>>>.....<<<<.<<<<<....>>>>>.>>>>....
<......>.....>>>>>..>>>>>>>>>><<<.....<....<<<<<<<
.......>>>>>>>..>.......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<.<.........>>>>>>.<<........>>...>>>>>>
......<...<<....<<<<....>>>>..>>..>.>.>>>>>>..<<<<
......<<<......>>>.....>>>>...<<<<<<......<.<<<<..
...>>>>..>.......>>>>>.>....<<<<<(((...<<<<<.....<
..))).>.......>>>>>>>>>>...>>>>..>>..........<<<((
.....<<<<...<<<.<<<<....<<<<<<<<<<......<<<<<<....
.>>>>>>....>>>>>>>..>>>...>>>>....<...<<.....<<<<<
<....<<<<<<<....<<........>>.......>>>>>>>........
...<......>.>>>>>>...>>.....>....>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>
>>.>>>.<<<......<<<<....>>>>....>>>...)))..<<<<<.<
<<<<<<....<<<<<<...<<<<<<<........<<........>>....
......<<<<.......................<........>.......
........................<.......<<<<<<<.......<<<<
<<<<....>>>..<<<<......>>>>..>>>>>......<<<<.<<<<<
<<...<..............>.....>>>>>>>.....<<<<<....>>>
>>........>>>>.......>.>>>...>>>.....>......>>.>>.
....>>>>>>>......<<<<.........<...<...<<<<....>>>>
...>.....>.........>>>>......<....<<<<<<<........>
>>>>>>....>.....>>>>>>.....<<<<<............>>>>>.
...........>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<
<<<<<<<<<...<..<<.....<........>..>>..>..>>>>>>>>>
>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>
>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gzz Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Resolution4.13 Å
Binding residue
(original residue number in PDB)		M1 L2 T3 T11 R12 N15 R18 K21 A28 S29 R30 F31 K56 P57 Y58 K88 R91 Y94 V97 S113 T114 S115 K116 G130
Binding residue
(residue number reindexed from 1)		M1 L2 T3 T11 R12 N15 R18 K21 A28 S29 R30 F31 K56 P57 Y58 K88 R91 Y94 V97 S113 T114 S115 K116 G130
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6gzz, PDBe:6gzz, PDBj:6gzz
PDBsum6gzz
PubMed30301898
UniProtP0DOY9|RS8_THET8 Small ribosomal subunit protein uS8 (Gene Name=rpsH)

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