Structure of PDB 7a01 Chain H2 Binding Site BS01

Receptor Information

>7a01 Chain H2 (length=153) Species: 9986 (Oryctolagus cuniculus)

VRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDV
TLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESN
AELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILT
EKE

Ligand information

>7a01 Chain e2 (length=3825)

cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggguccggccgugucggcgg
cccggcggaucuuucccgccccccguggggucggcgggggaccguccccc
gaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggc
ccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccg
agggagcgagacccgucgccgcgcucuccccccucggcgucuccucgugg
gggggccgggccaccccucccacggcgcgaccgcucucccaccccucguc
ggggggcggggcggacuguccccagugcgccccgggcgggucgcgccguc
gggcccgggggagguucucucggggccacgcgcgcgucccccgaagaggg
ggacggcggagcgagcgcacggggucggcggcgacgucggcuacccaccc
gacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucggg
ggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcu
cgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcac
caccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacg
uguuaggacccgaaagauggugaacuaugccugggcagggcgaagccaga
ggaaacucugguggagguccguagcgguccugacgugcaaaucggucguc
cgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguu
cccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgca
cccccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggg
gccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccg
gcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuu
ugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcg
cccgaugccgacgcucaucagaccccagaaaagguguugguugauauaga
cagcaggacgguggccauggaagucggaauccgcuaaggaguguguaaca
acucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcguc
gggcccauacccggccgucgccggcagucgagaguggacgggagcggcgg
gggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccg
cgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggc
ccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauuc
aaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagca
guugaacaugggucagucgguccugagagaugggcgagcgccguuccgaa
gggacgggcgauggccuccguugcccucggccgaucgaaagggagucggg
uucagauccccgaauccggaguggcggagaugggcgccgcgaggcgucca
gugcgguaacgcgaccgaucccggagaagccggcgggagccccggggaga
guucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccg
agagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggu
gagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcg
ccgggccguacccauauccgcagcaggucuccaaggugaacagccucugg
cauguuggaacaauguagguaagggaagucggcaagccggauccguaacu
ucgggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcg
gaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccg
cggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaa
gugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacuc
ucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaug
gaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagc
caagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagc
uugacucuagucuggcacggugaagagacaugagagguguagaauaagug
ggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggg
uccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuu
uucacugacccggugaggcgggggggcgagccccgaggggcucucgcuuc
uggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccgggg
acagugccagguggggaguuugacuggggcgguacaccugucaaacggua
acgcagguguccuaaggcgagcucagggaggacagaaaccucccguggag
cagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagacc
gugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcagga
ggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgu
ucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauu
gugaagcagaauucaccaagcguuggauuguucacccacuaauagggaac
gugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugau
gauguguuguugccaugguaauccugcucaguacgagaggaaccgcaggu
ucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcua
ccaucugugggauuaugacugaacgccucuaagucagaaucccgcccagg
cggaacgauacggcagcgccgcggagccucgguuggccucggauagccgg
ucccccgccgggaccgggguccggugcggagugcccuucguccugggaaa
cggggcgcggccggagaggcggccgcccccucgcccgucacgcaccggcc
guucguggggaaccuggcgcuaaaccauucguagacgaccugcuucuggg
ucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaa
gucagcccucgacacaaggguuugu

.........................<<<<<<.....<......>......
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>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>...
..>>>>...<<<<<<<<<....<<<<<<<<........<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....(((((..<<<<<<)))))..]]]..................
................<<....>>...............<<<......>>
>....................................<<<<<...<<<..
....<<<<<<<<.<<<.....<<<<<<<<<<<...<<<.<<.<<<<<.<<
...<<<<<.<<..<<<<<<<<<<<..>>>>..>>>>>>>>>>>>>>>>>>
>>>>>....>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<
<<<.<<<<<<<<<..<<<....<.....<<<<.<<.<...<...<<<<<.
>>>>>...>.....>>>.>>>>..........>.>>>....>>>>>>>>>
....................<<<<<..<<<<<<................>
>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<........<<<<....
.>>>>..<<<<<<.<<<<....>>>>.>>>>>>..>>.>>>>>>>>>>>.
>>>...>.>>>...........>>.>...........<<.<........>
>>...........>>>>>......>>>.>>>>>....>>>....>>>>>.
...<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...
<<<<........>>>>.....>>>...<<....>>...<<<<<<<.....
.>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>
>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<
<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
<<<<<<....<.<<<....>>>(><<.<<<<<<<................
..............<<<<<<<<....<<<....<<<..<.<<<..<.<..
............>.>.>>>.>..>>>..>.>>....>>>>>>...<<<<<
<<<<........>>>>>>>>>...>>...>>>>>>>..>>).<<<<.<<<
<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(
((.......<<<<<......<..........<<<.<<<<<<<<<<.....
..<<<...<<<...................>>>.........<<......
>>.....>>>...>>>>>>>>>>>>>..........))).>....>>>>>
..>>>...>>>>>>><<<<<<.<<<..........]]..)))........
..............................................>>>>
>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>
>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<
<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<...
..>>.>>>>>>....((<<<<<<...<<....<<<....>>>........
..<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<
........>>>>>))<<<<....<<<<....<<<<<<......>>>>>>.
..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<
<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.
....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.
..>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.
>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>
>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<
..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>......
......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.
....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....
.<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>
>.........<...........<<<<<.......>>>>>.....>.....
>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<
<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[
[..<<<<<.<<<<<<<<<.<<<<<<<<<<.....<..............<
.........<<<<<<<<.<<<<...<.<........>>..>>>.>..>>>
..>>>>>........................>......>......>>>>>
>>>>>...<<<<<.....<<<<...<.<<<<<<....>>>>>>>......
.........<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>.
...>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<.........
..>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<
<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<
<<....>>>.>>)))]......((((((..(((..>>>>>>.))))))))
)..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<..
.....>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.
<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..
>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]
.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.
><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>
...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>..
.>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<
..<<.<<.......>.>>>.>>>>>........>>....<<..<<<<...
.<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>.........
.......>>>..>>>>>>>>><<<<<....................<<.<
<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>
>....>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7a01 The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): R3 Y4 L6 K16 S17 R18 S20 H25 F26 K27 R30 Q34 K37 K54 R62 Y63 N64 G65 G66 R69 A71 Q72 Q75 Q80 R82 W83 K86 H93 K96 N97 S100 N101 L104 Q118 V119 R127 T129 Y130 R131 A132 H133 G134 R135 I136 N137 P138 Y139 M140 S141
• Binding residue (residue number reindexed from 1): R2 Y3 L5 K15 S16 R17 S19 H24 F25 K26 R29 Q33 K36 K53 R61 Y62 N63 G64 G65 R68 A70 Q71 Q74 Q79 R81 W82 K85 H92 K95 N96 S99 N100 L103 Q117 V118 R126 T128 Y129 R130 A131 H132 G133 R134 I135 N136 P137 Y138 M139 S140

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit

External links

• PDB: RCSB:7a01, PDBe:7a01, PDBj:7a01
• PDBsum: 7a01
• PubMed: 33296660
• UniProt: G1SCJ6|RL17_RABIT Large ribosomal subunit protein uL22 (Gene Name=RPL17)