Structure of PDB 8rhk Chain H Binding Site BS01

Receptor Information

>8rhk Chain H (length=222) Species: 4932 (Saccharomyces cerevisiae)

TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAA
DTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIV
AGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEE
AIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ
KSYKFPRGTTAVLKESIVNICD

Ligand information

>8rhk Chain e (length=4) Species: 32630 (synthetic construct)

FLWG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rhk Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): T6 T26 Q27 G52 T53 A54 G173
• Binding residue (residue number reindexed from 1): T1 T21 Q22 G47 T48 A49 G168

Enzymatic activity

• Enzyme Commision number: 3.4.25.1: proteasome endopeptidase complex.

Gene Ontology

Molecular Function

• GO:0004298 threonine-type endopeptidase activity

Biological Process

• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0005839 proteasome core complex

External links

• PDB: RCSB:8rhk, PDBe:8rhk, PDBj:8rhk
• PDBsum: 8rhk
• PubMed: 38628795
• UniProt: P25043|PSB2_YEAST Proteasome subunit beta type-2 (Gene Name=PUP1)