Structure of PDB 8ppk Chain H Binding Site BS01

Receptor Information
>8ppk Chain H (length=189) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGG
GRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPT
RKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIK
VHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL
Ligand information
>8ppk Chain 2 (length=1771) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuugguga
cucuagauaaccucgggccgaucgcacgccccccguggcggcgacgaccc
auucgaacgucugcccuaucaacuuucgaugguagucgccgugccuacca
uggugaccacgggugacggggaaucaggguucgauuccggagagggagcc
ugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuaccc
acucccgacccggggagguagugacgaaaaauaacaauacaggacucuuu
cgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauc
cauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaau
agcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuggg
agcgggcggccguccccgccccgccucucggcgccccggggcccgaagcg
uuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggau
accgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuu
ucggaacugaggccaugauuaagagggacggccgggggcauucguauugc
gccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaa
gcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucg
aagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggc
gaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaacca
aagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaagg
aauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacu
caacacgggaaaccucacccggcccggacacggacaggauugacagauug
auagcucuuucucgauuccgugggugguggugcauggccguucuuaguug
guggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaug
cuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuaga
gggacaaguggcguucagccacccgagauugagcaauaacaggucuguga
ugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcg
ugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucg
ugauggggaucggggauugcaauuauuccccaugaacgaggaauucccag
uaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacac
accgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucg
gccccgccggggucggcccacggcccuggcggagcgcugagaagacgguc
gaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggu
gaaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[{..........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<....
..>..)))))......]]...<<<<.<<<<......>>>>>>>>..}.]]
]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>
>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<.
.........>>>.>>.<.<<....>>.>...]]]]]].........<<<.
...<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<...
.>>>..>>>>>>.>>>......<<..<...........>..>>.......
..<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>.
.)))))).]]]............{{.......{{...[[[.[[....<<<
.<.<<<<<..>>>>>.>.>>>.<<...<<<..<<<<<>>>>>.>>>.>>.
.<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>
>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>
>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<
<<<<...<<<......>>>......>>>>>>>>..>>.......<<....
>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<.
..<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<
..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>.
..>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]
]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<...
.....>>..........<<<<<......<<<<<<.......<<.<<<...
.....>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.
<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...
<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>.
.>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>
>>>>>>>......>>>>>......>>>>.>>>.....<<.<<<.......
.<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>.
...........<<<<<..........>>>>>...........>>>>>...
..<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.
......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<
<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>
..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<.
...>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ppk Universal features of Nsp1-mediated translational shutdown by coronaviruses.
Resolution2.98 Å
Binding residue
(original residue number in PDB)
P67 R98 R99 I100 P102 K103 R106 K107 S108 R109 T110 K111 Q114 K115 R116 P117 R118 S119 R120 T121 L122 T123
Binding residue
(residue number reindexed from 1)
P62 R93 R94 I95 P97 K98 R101 K102 S103 R104 T105 K106 Q109 K110 R111 P112 R113 S114 R115 T116 L117 T118
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0048027 mRNA 5'-UTR binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0001843 neural tube closure
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0010628 positive regulation of gene expression
GO:0014033 neural crest cell differentiation
GO:0042274 ribosomal small subunit biogenesis
GO:0050821 protein stabilization
GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0032991 protein-containing complex
GO:0045202 synapse
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8ppk, PDBe:8ppk, PDBj:8ppk
PDBsum8ppk
PubMed37802027
UniProtP62081|RS7_HUMAN Small ribosomal subunit protein eS7 (Gene Name=RPS7)

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