Structure of PDB 8of4 Chain H Binding Site BS01

Receptor Information
>8of4 Chain H (length=99) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKRRKTRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGE
ASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK
Ligand information
>8of4 Chain I (length=145) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggg
gattactccctagtctccaggcacgtgtcagatatatacatcgat
Receptor-Ligand Complex Structure
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PDB8of4 Binding to nucleosome poises SIRT6 for histone H3 de-acetylation
Resolution2.94 Å
Binding residue
(original residue number in PDB)		R27 R30 K31 S33 I36 Y37
Binding residue
(residue number reindexed from 1)		R4 R7 K8 S10 I13 Y14
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:8of4, PDBe:8of4, PDBj:8of4
PDBsum8of4
PubMed38415718
UniProtP02281|H2B11_XENLA Histone H2B 1.1

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