Structure of PDB 8bw5 Chain H Binding Site BS01

Receptor Information
>8bw5 Chain H (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
Ligand information
>8bw5 Chain F (length=40) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggtcagatgatggggatggggggttggaggaatggatgac
Receptor-Ligand Complex Structure
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PDB8bw5 Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		I24 R75 Y76 E77 R77A N78 I79 I82 Y117
Binding residue
(residue number reindexed from 1)		I9 R70 Y71 E72 R73 N74 I75 I78 Y114
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:8bw5, PDBe:8bw5, PDBj:8bw5
PDBsum8bw5
PubMed37503836
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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