Structure of PDB 8ase Chain H Binding Site BS01

Receptor Information
>8ase Chain H (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHYERNIEKISMLEKIYIHPRYNWRENLDRDIALMK
LKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGK
GQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGD
SGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
DQF
Ligand information
>8ase Chain L (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB8ase Crystal structure of Thrombin in complex with optimized macrocycles T1 and T3
Resolution2.55 Å
Binding residue
(original residue number in PDB)		E23 M26 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 P204 N205 R206 W207
Binding residue
(residue number reindexed from 1)		E8 M11 W14 D109 H112 P113 C115 Y130 K131 R133 N160 M207 K208 P210 N213 R214 W215
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:8ase, PDBe:8ase, PDBj:8ase
PDBsum8ase
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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