Structure of PDB 7zkm Chain H Binding Site BS01

Receptor Information
>7zkm Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEQPSV
LQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPF
VMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Ligand information
>7zkm Chain L (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB7zkm A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E23 I24 G25 M26 W29 D116 H119 P120 C122 Y134 K135 R137 N159 K202 P204 N205 R206 W207
Binding residue
(residue number reindexed from 1)		E8 I9 G10 M11 W14 D113 H116 P117 C119 Y134 K135 R137 N155 K203 P205 N208 R209 W210
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7zkm, PDBe:7zkm, PDBj:7zkm
PDBsum7zkm
PubMed36457701
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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