Structure of PDB 7wtt Chain H Binding Site BS01

Receptor Information
>7wtt Chain H (length=186) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGR
KAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRK
SRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVH
LDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQ
Ligand information
>7wtt Chain 2 (length=1575) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccaauuccagcuc
caauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucu
cucucggccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggc
cgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuu
uguugguuuucggaacugaggccaugauuaagagggacggccgggggcau
ucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggacc
agagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaaguc
ggagguucgaagacgauaccgucguaguuccgaccauaaacgaugccgac
cggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaa
accaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuua
aaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuu
gcacccggcccggacacggacaggauugacagauugauagcucuuucucg
auuccgugggugguggugcauggccguuguuggcugguuaauuccgauga
acgagacucuggcaugcuauucuuagagggacaaguggcguucagccacc
cgagauugagcuaacaggucugugaugcccuguccggggcugcacgcgcg
cuacacugacuggcucagcguguccuacgccggcaggcgcggguaacccg
uugaaccccauucgugauggggaucggggauugcaauuauuccccaugaa
cgaggaauucccaguaagugcgggucauaagcuugcguugauuaaguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagug
aggcccucggaucggccccgccggggugcccuggcggagcgcugagaaga
cggucgaacuugacuaucuagaggaaguaaaagucgagguuuccguaggu
gaaccugcggaaggaucauuaacgg
...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<..........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<.......
....>..>>.........<<<<<........<<<<........>>>>.>>
>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...
<<.<<<..>>>>>...<<<<<<.........<<...<.......>.<<<<
.>>>>...>>........>>>..>>>........<.<<.<<<<<<<....
...........>>>>>>>.>>.>....>>....<<<<<<..<...<<<<.
.<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>....
...<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<
<<<<...<...<<<<....>>>>...>>>>>>>>..........<<<.<<
.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..)
)>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>.
.)))).]]....<<<<<<<<..<<..<<<<<.<<<<.<<<<<<.......
...<<<<<....<.<<<<<<.......<<.<<<........>>>.>>...
..>>>>>>..>...<<<.<<.<<<<<<.<<<...<<<......>>>...>
>>....<<<...<...<<<....>>>..>.....<<<<<.....>>>>>.
.......>>>...>>.>>>>..>>..>>>....>>>>>...>>.>>>>.>
>>.>...<<.<<<........<.<<<.<<<<....>>>>.>>>....>..
.......>>>.>>......<.....<<<<<..........>>>>>.....
>.....>>>>>.....<<<<<<<<<.....>>>>>>>>>......>>...
>>>>>>>>......<<<...<<....<<<<.<<....<<<<<<<<.<<<.
.<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>
.>>>>..>>>.>>>>>>>>...>>.>>>>.....>>.>>><<<<<<<<<.
...>>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wtt The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		V66 P67 R98 R99 K103 T105 R106 K107 S108 R109 K113 Q114 K115 R116 P117 R118 S119 R120 L122 T123
Binding residue
(residue number reindexed from 1)		V59 P60 R91 R92 K96 T98 R99 K100 S101 R102 K106 Q107 K108 R109 P110 R111 S112 R113 L115 T116
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0048027 mRNA 5'-UTR binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0001843 neural tube closure
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0010628 positive regulation of gene expression
GO:0014033 neural crest cell differentiation
GO:0042274 ribosomal small subunit biogenesis
GO:0050821 protein stabilization
GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0032991 protein-containing complex
GO:0045202 synapse
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wtt, PDBe:7wtt, PDBj:7wtt
PDBsum7wtt
PubMed36321656
UniProtP62081|RS7_HUMAN Small ribosomal subunit protein eS7 (Gene Name=RPS7)

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