Structure of PDB 7wf3 Chain H Binding Site BS01

Receptor Information
>7wf3 Chain H (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLP
EFRSSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVA
IIPYFITLGTELAERQGSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTL
KASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVT
MTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET
EG
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain7wf3 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7wf3 Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		G446 G448
Binding residue
(residue number reindexed from 1)		G205 G207
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005249 voltage-gated potassium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wf3, PDBe:7wf3, PDBj:7wf3
PDBsum7wf3
PubMed35091471
UniProtP22001|KCNA3_HUMAN Potassium voltage-gated channel subfamily A member 3 (Gene Name=KCNA3)

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