Structure of PDB 7tan Chain H Binding Site BS01

Receptor Information
>7tan Chain H (length=93) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLA
HYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSS
Ligand information
>7tan Chain I (length=147) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggatgtatatatctgacacgtgcctggagactagggagtaatccccttgg
cggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgctagag
ctgtctacgaccaattgagcggcctcggcaccgggattctccagggc
Receptor-Ligand Complex Structure
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PDB7tan Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R33 K34 Y40
Binding residue
(residue number reindexed from 1)		R2 K3 Y9
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0006334 nucleosome assembly
GO:0019731 antibacterial humoral response
GO:0042742 defense response to bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Cellular Component
GO:0000786 nucleosome
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tan, PDBe:7tan, PDBj:7tan
PDBsum7tan
PubMed35390161
UniProtP62807|H2B1C_HUMAN Histone H2B type 1-C/E/F/G/I (Gene Name=H2BC4)

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