Structure of PDB 7syl Chain H Binding Site BS01

Receptor Information
>7syl Chain H (length=237) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVV
RISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGC
IVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKE
DDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTK
KNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSL
Ligand information
>7syl Chain 2 (length=1697) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaau
ucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggau
gcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgc
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucuugggagcggccguccccugcucggcgccggcccgaagc
guuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgc
agcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucgga
acugaggccaugauuaagagggacggccgggggcauucguauugcgccgc
uagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauu
ugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagac
gaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugc
ggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaaguc
uuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuu
ggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaaca
cgggaaaccucacccggcccggacacggacaggauugacagauugauagc
ucuuucucgauuccgugggugguggugcauggccguucuuaguuggugga
gcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaac
uaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguu
cagccacccgagauugagcaauaacaggucugugaugcccuuagaugucc
ggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacg
ccggcaggcgcggguaacccguugaaccccauucgugauggggaucgggg
auugcaauuauuccccaugaacgaggaauucccaguaagugcgggucaua
agcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuac
uaccgauuggaugguuuagugaggcccucggaucggccccgccggggugc
ccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaagua
aaagucguaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<..........<<.....<<.<<.....
..>>.>>......>>.........<<<<...<<<<<<....>>>>>>...
>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<
<.>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>
>>>.........<<<....<<<.....>>>..>>>......>>.>.....
<<<.<<<<<.<<<....>>>..>>>>>..>>>......<...<.......
....>...>.........<<<<<((....<.<<<<.....<<..))>>..
.....>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<....<<<.<.<..>.>.>>>.<<<<...<<..>>..>>.>>
..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>....
..>.>>>..>>>........<.<<.<<<<<<<...............>>>
>>>>.>>.>....>>....<<<<<.<.....<<<<..<<<.<<<<<<<<.
..<<<......>>>......>>>>>>>>.>>>.......<<....>>...
>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<
<.........>>>>...>.>>>>>>..........<<<.<<.<<<..<.<
<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.
....>>>.>.>.<<<......<<<......>>>....>>>..))))..].
<...<<<<<<<..<<..<<<<<..<<<.<<<<<<.......<........
>...........<<<<<......<<<<<<...........<<........
>>.........>>>>>>...<<.<<<..<..<<<<<.....<<<.<<<<<
....>>>...<<<......>>>...>>.>>>....<<<...<...<.<<.
.<<<<<<<<<<<<..>>>>.>>>>>>>>..>>.>..>.....<<<<<...
..>>>>>........>>>.....>>.>>>......>>>>>>.......>>
>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<
<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<
<..........>>>>>>....>.....>>>>>.....<<<<<<<<.....
..>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<
<.<<....<<<<<<<<.<<<...<<<.<<...<<<<<..<<<<<<<....
>>>>>>>....>>>>>...>>.>>>...>>>.>>>>>>>>...>>.>>>>
...>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
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PDB7syl Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		N4 S6 P8 Q13 K14 L15 R31 S53 Q59 G60 Q65 R74 H81 S82 C83 Y84 R87 R88 T89 G90 E91 R92 R94 K95 N110 V112 R131 L133 G134 K136 R137 S139 R140 Q155 R159 K160 L162 N163 K164 K167 R170 T171 K172 P174 K175 I176 Q177 R178 V180 R183 Q186 H187 R189 R190 R191 A193 K196 R198 T199 K230
Binding residue
(residue number reindexed from 1)		N4 S6 P8 Q13 K14 L15 R31 S53 Q59 G60 Q65 R74 H81 S82 C83 Y84 R87 R88 T89 G90 E91 R92 R94 K95 N110 V112 R131 L133 G134 K136 R137 S139 R140 Q155 R159 K160 L162 N163 K164 K167 R170 T171 K172 P174 K175 I176 Q177 R178 V180 R183 Q186 H187 R189 R190 R191 A193 K196 R198 T199 K230
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7syl, PDBe:7syl, PDBj:7syl
PDBsum7syl
PubMed35822879
UniProtA0A5K1UJS7

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