Structure of PDB 7po7 Chain H Binding Site BS01

Receptor Information
>7po7 Chain H (length=311) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARCVRLSAERAKLLLAEVDTLLFNCDGVLWRGETAVPGAPETLRALRARG
KRLGFITNNSSKTRTAYAEKLRRLGFGGPVGPEAGLEVFGTAYCSALYLR
QRLAGVPDPKAYVLGSPALAAELEAVGVTSVGVGPDVLHGDGPSDWLAVP
LEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPDCLLVGTNMDNRLPLENGR
FIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGD
RLDTDILLGSTCSLKTILTLTGVSSLEDVKSNQESDSMFKKKMVPDFYVD
SIADLLPALQG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7po7 Chain H Residue 406 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7po7 Discovery of a small-molecule inhibitor of the metabolic damage control enzyme phosphoglycolate phosphatase
Resolution2.31 Å
Binding residue
(original residue number in PDB)		S70 F172 T198 N199
Binding residue
(residue number reindexed from 1)		S60 F162 T188 N189
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.21: glycerol-1-phosphatase.
3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0000121 glycerol-1-phosphatase activity
GO:0000287 magnesium ion binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008967 phosphoglycolate phosphatase activity
GO:0016791 phosphatase activity
GO:0043136 glycerol-3-phosphatase activity
GO:0043262 ADP phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006114 glycerol biosynthetic process
GO:0006650 glycerophospholipid metabolic process
GO:0045721 negative regulation of gluconeogenesis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7po7, PDBe:7po7, PDBj:7po7
PDBsum7po7
PubMed36369173
UniProtQ8CHP8|PGP_MOUSE Glycerol-3-phosphate phosphatase (Gene Name=Pgp)

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