Structure of PDB 7oni Chain H Binding Site BS01

Receptor Information
>7oni Chain H (length=380) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IEDYYVGVASDVEQQGFDPEEYQFTCLTYKESEGALNEHMTSLASVLKVS
HSVAKLILVNFHWQVSEILDRYKSNSAQLLVEARVQPNPSHPPHHCAVCM
QFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTP
EDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPR
ARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADNQSQQAQAREA
LKKYLFYFERWENHNKSLQAAAQTYQRIHEKIQERVMNNLGTWIDWQYLQ
NAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIANLSWKV
ERADSYDRGDLENQMHIAEQRRRTLLKDFH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7oni Chain H Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7oni CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C257 H265 C270
Binding residue
(residue number reindexed from 1)		C214 H222 C227
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0031624 ubiquitin conjugating enzyme binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048588 developmental cell growth
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0071425 hematopoietic stem cell proliferation
GO:1903955 positive regulation of protein targeting to mitochondrion
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031466 Cul5-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oni, PDBe:7oni, PDBj:7oni
PDBsum7oni
PubMed34518685
UniProtO95376|ARI2_HUMAN E3 ubiquitin-protein ligase ARIH2 (Gene Name=ARIH2)

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