Structure of PDB 7of3 Chain H Binding Site BS01

Receptor Information

>7of3 Chain H (length=95) Species: 9606 (Homo sapiens)

TVIVERWWKVPLAGEGRKPRLHRRHRVYKLVEDTKHRPKENLELILTQSV
ENVGVRGDLVSVKKSLGRNRLLPQGLAVYASPENKKLFEEEKLLR

Ligand information

>7of3 Chain A (length=1386)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacccaaauaaaguauaggcgauagaaauugaaauggcgcaauag
auauaguaccgcaagggaaagaugaaaaacaagcauaauauagcaaggac
uaaccccuauaccuucugcaaugaauuaacuagaaauaacuuugcaagga
gagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcua
aaagagcacacccgucuauguagcaaaauagugggaagauuuauagguag
aggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaau
cuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccuuccuuaaauaggga
uggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugac
cugcccgugagaggcgggcauaacacagcaagacgagagacccuauggag
cuuuaauuuauuaaugcaaacaaccugcauuaaaaauuucgguuggggcg
accucggagcagaacccaaccuccgagcaguacaugcuaagacuucacca
gucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguua
cccuagggaaauccuauucuagaguccauaucaacaauaggguuuacgac
cucguuggaucaggacaucccgauggugcagccgcuauuaaagguucguu
uguucaacgauuaaaguccuacgugaucugaguucagaccggaguaaucc
aggucgguuucuaucuacuuuaauuccucccuguacgaaaggacaagaga
aauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucuca
acuuaguauuauacccacacacccaagaacaggguu

<<<.......<<<<.................................<..
....>...............<<.....>>...........>>.>>.....
........<<....>>...............>>>...........<<<..
.....>>>...<.<<....>>.>.<<<<<<.........<<<.<<..<<.
...>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.
....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>..
.<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<
....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<....[.>>>>>>>>>>...<<<......>>>
....<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>>.......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<.<<<<.....>>>>.
.>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.........
..<<<<<.......>>>>>.......<<..<<<.<<<...<<<<<.<<<<
<<..<<<<<.<<<<<<<<.......>>>>>>>>>>>>>..<<<<((((.>
>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>
>>>..>>>....>>.........<<<....>>>............>>>>.
.>>>>>>>.<<<<<<<<<...<<.......>>...>>>>>>>>>]....)
))).<<<<<..<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<
.....>>>>>.....>>>>>......>>>>>.....<<<<<<<....>>>
.>>>>...>>>..>>>.>>...<<<.<<<.................>>>.
>>><<<<<...<<<....>>>.>>>>>......<<<..............
..>>>...............<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of3 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): W60 K61 P63 L64 A65 G66 R69 R72 H74 R75 R76 R78 D85 K87 H88 K91 S117 N121
• Binding residue (residue number reindexed from 1): W8 K9 P11 L12 A13 G14 R17 R20 H22 R23 R24 R26 D33 K35 H36 K39 S65 N69

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of3, PDBe:7of3, PDBj:7of3
• PDBsum: 7of3
• PubMed: 34135319
• UniProt: Q9BYD2|RM09_HUMAN Large ribosomal subunit protein bL9m (Gene Name=MRPL9)