Structure of PDB 7nyc Chain H Binding Site BS01

Receptor Information
>7nyc Chain H (length=404) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQC
VPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEP
RPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGN
TLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKLSYSSKKEKMFLH
VKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTHY
SSSGSLGGLYELIYVLDKASMKRKAVNITSENLIDDVVSLIRGGTRKYAF
ELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAH
LKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFEGIA
CEIS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7nyc Chain H Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7nyc Structural basis of soluble membrane attack complex packaging for clearance.
Resolution3.54 Å
Binding residue
(original residue number in PDB)		L96 R97 N99 D101 D103 E110
Binding residue
(residue number reindexed from 1)		L79 R80 N82 D84 D86 E93
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0001906 cell killing
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0044218 other organism cell membrane
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7nyc, PDBe:7nyc, PDBj:7nyc
PDBsum7nyc
PubMed34667172
UniProtP02748|CO9_HUMAN Complement component C9 (Gene Name=C9)

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