Structure of PDB 7lep Chain H Binding Site BS01

Receptor Information
>7lep Chain H (length=164) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQVLLTTIGAFSAFGLMTIAISTDYWLYTRGLTHSGLWRICCLEGLKRGV
CVKINHFAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIIL
GAGILFVAAGLSNIIGVIVYISANAGKNHYSYGWSFYFGGLSFILAEVIG
VLAVNIYIERSREA
Ligand information
Ligand IDXVD
InChIInChI=1S/C14H8ClF3N2O2/c15-8-2-1-3-11(22-14(16,17)18)12(8)7-4-5-9-10(6-7)20-13(21)19-9/h1-6H,(H2,19,20,21)
InChIKeyCOBXSLRIXGQVGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1cc(c(c(c1)Cl)c2ccc3c(c2)[nH]c(n3)O)OC(F)(F)F
CACTVS 3.385Oc1[nH]c2cc(ccc2n1)c3c(Cl)cccc3OC(F)(F)F
ACDLabs 12.01n3c2c(cc(c1c(cccc1Cl)OC(F)(F)F)cc2)nc3O
FormulaC14 H8 Cl F3 N2 O2
Name6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol
ChEMBLCHEMBL4214902
DrugBank
ZINC
PDB chain7lep Chain H Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7lep Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		N172 V176 F205 G208 G209
Binding residue
(residue number reindexed from 1)		N113 V117 F136 G139 G140
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006816 calcium ion transport
Cellular Component
GO:0016020 membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7lep, PDBe:7lep, PDBj:7lep
PDBsum7lep
PubMed33981040
UniProtQ8VHW2|CCG8_MOUSE Voltage-dependent calcium channel gamma-8 subunit (Gene Name=Cacng8)

[Back to BioLiP]