Structure of PDB 7lde Chain H Binding Site BS01

Receptor Information
>7lde Chain H (length=162) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQVLLTTIGAFSAFGLMTIAISTDYWLYTRGLTHSGLWRICCLEGLKRGV
CVKINHFAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIIL
GAGILFVAAGLSNIIGVIVYISANAGKNHYSYGWSFYFGGLSFILAEVIG
VLAVNIYIERSR
Ligand information
Ligand IDXVD
InChIInChI=1S/C14H8ClF3N2O2/c15-8-2-1-3-11(22-14(16,17)18)12(8)7-4-5-9-10(6-7)20-13(21)19-9/h1-6H,(H2,19,20,21)
InChIKeyCOBXSLRIXGQVGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1cc(c(c(c1)Cl)c2ccc3c(c2)[nH]c(n3)O)OC(F)(F)F
CACTVS 3.385Oc1[nH]c2cc(ccc2n1)c3c(Cl)cccc3OC(F)(F)F
ACDLabs 12.01n3c2c(cc(c1c(cccc1Cl)OC(F)(F)F)cc2)nc3O
FormulaC14 H8 Cl F3 N2 O2
Name6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol
ChEMBLCHEMBL4214902
DrugBank
ZINC
PDB chain7lde Chain H Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7lde Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		N172 V176 I180 F205 G208 G209
Binding residue
(residue number reindexed from 1)		N113 V117 I121 F136 G139 G140
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005246 calcium channel regulator activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006816 calcium ion transport
GO:0070588 calcium ion transmembrane transport
GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
GO:2000311 regulation of AMPA receptor activity
Cellular Component
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0032281 AMPA glutamate receptor complex
GO:0034702 monoatomic ion channel complex
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098839 postsynaptic density membrane
GO:0098978 glutamatergic synapse
GO:1990454 L-type voltage-gated calcium channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lde, PDBe:7lde, PDBj:7lde
PDBsum7lde
PubMed33981040
UniProtQ8VHW2|CCG8_MOUSE Voltage-dependent calcium channel gamma-8 subunit (Gene Name=Cacng8)

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