Structure of PDB 7kd6 Chain H Binding Site BS01

Receptor Information

>7kd6 Chain H (length=47) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

FVNQHLCGSHLVEALYLVCGERGFFRGIVEQCCHSICSLEQLENYCN

Ligand information

>7kd6 Chain L (length=15) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

TFEDYLHNVVFVPRP

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	7kd6 Single-chain insulin analogs threaded by the insulin receptor alpha CT domain.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	G8 V12 L15 F24 F25 R36 G37 I38 V39 N54 Y55 C56
Binding residue (residue number reindexed from 1)	G8 V12 L15 F24 F25 R26 G27 I28 V29 N44 Y45 C46

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005179	hormone activity

	Cellular Component
GO:0005576	extracellular region

View graph for
Molecular Function

View graph for
Cellular Component

External links

PDB	RCSB:7kd6, PDBe:7kd6, PDBj:7kd6
PDBsum	7kd6
PubMed	36181268
UniProt	P01308\|INS_HUMAN Insulin (Gene Name=INS)

[Back to BioLiP]