Structure of PDB 6z8v Chain H Binding Site BS01

Receptor Information

>6z8v Chain H (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FG

Ligand information

>6z8v Chain L (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ADCGLRPLFEKKSLEDKTERELLESYI

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6z8v Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12.
Resolution	1.58 Å
Binding residue (original residue number in PDB)	E23 G25 M26 P28 W29 D116 H119 C122 Y134 K135 R137 N159 K202 P204 N205 R206 W207
Binding residue (residue number reindexed from 1)	E8 G10 M11 P13 W14 D113 H116 C119 Y134 K135 R137 N158 K206 P208 N211 R212 W213

Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)	H43 D99 E196 G197 D198 S199 G200
Enzyme Commision number	3.4.21.5: thrombin.

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

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Molecular Function

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Biological Process

External links

PDB	RCSB:6z8v, PDBe:6z8v, PDBj:6z8v
PDBsum	6z8v
PubMed	33614235
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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