Structure of PDB 6yhj Chain H Binding Site BS01

Receptor Information
>6yhj Chain H (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWKG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
QFG
Ligand information
Receptor-Ligand Complex Structure
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PDB6yhj Thrombin in complex with D-Phe-Pro-2-chlorothiophen derivative (16e)
Resolution1.44 Å
Binding residue
(original residue number in PDB)		F34 L40 L65 R73 T74 R75 Y76 K81 I82
Binding residue
(residue number reindexed from 1)		F19 L26 L60 R68 T69 R70 Y71 K77 I78
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E197 G198 D199 S200 G201
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6yhj, PDBe:6yhj, PDBj:6yhj
PDBsum6yhj
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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