Structure of PDB 6x34 Chain H Binding Site BS01

Receptor Information
>6x34 Chain H (length=3715) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDL
AICCFVLEQSLSVRALQEMLANGHRTLLYGHAILLRHAHSGMYLSCLTTS
RSMTDKLAFDVGLQEDATGEACWWTTHPASKQRSEGEKVRVGDDLILVSV
SSERYLHLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLFH
GHMDECLTISPADSDDQRRLVYYEGGSVCTHARSLWRLEPLRISWSGSHL
RWGQPLRIRHVTTGRYLALIEDQGLVVDASKAHTKATSFCFRISKEKLKR
DVEGMGPPEIKYGESLCFVQHVASGLWLTYAALKKKAILHQEGHMDDALS
LTRCQQEESQAARMIYSTAGLYNHFIKGLDSFSGKPRGSGAPAGTALPLE
GVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLN
CIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANCAL
FSNNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISL
LDKHGRNHKVLDVLCSLCVCNGVAVCSNQDLITENLLPGRELLLQTNLIN
YVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVVPFLTAQATHLRVGWALT
EGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVPRLVTSPGQHLLA
PEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLNGLFFPVVSFSAGVKV
RFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHL
VGPSRCLSHTDFVPCPLPPHLERIREKLAENIHELWALTRIEQGWTYGPV
RDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKA
EDNLRKTKLPKTYMMSNGYKPAPLDAQTTLVDRLAENGHNVWARDRVAQG
WSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIE
RVRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADEL
AYVFNGHRGQRWHLGSELFGRPWQSGDVVGCMIDLTENTIIFTLNGEVLM
SDSGSETAFRDIEVGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQ
EGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVSRVDGTVDTPPCL
RLTHRSLVEMLFLRLSLPVQFHQLNTTTYYYSVRVFAGQEPSCVWVGWVT
PDYHQHDMNFDLTKVRAVTVTMGDNIHSSLKCSNCYMVWGGDFVSHTDLV
IGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFE
LGKQKNIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLRV
ETRRAGERLGWAVPLTMMALHIPEENRCMDILELSERLDLQQFHSHTLRL
YRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIH
LESACRSRRSMLSEYIVPLTPETRAITLFPPRHGLPGVGVTTSLRPPHHF
SAPCFVAALPEAPARLSPSIPLEALRDKALRMLGEAVRDGGQHARDPVGG
SVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVEEGLLQMKLPES
VKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRYGILMKAF
TMTAAETARRTREFRSPPQEQINMLLHFKPLPDEIRQDLLEFHQDLLTHC
GIQLQSLQELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRA
LPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMN
NKVFYQHPNLMRALGMHETVMEVMVNVLRFPKMVTSCCRFLCYFCRISRQ
NQRSMFDHLSYLLENSGSTPLDVAAASVIDNNELALALQEQDLEKVVSYL
AGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANV
VVRLLIRKPECFGPALRLLATIEEAIAIMSFYAALIDLLGRCAPEMHLIQ
AGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTMSASFVPDHKASMVLF
LDRVYGFLLHVLDVGFALALNRYLCLAVLPLITKCAPLFAMVDSMLHTVY
RLSRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLVFAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADPRPVETLNVIIP
EKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFS
EKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDLSGVTLSRELQ
AMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREK
AQELLKFLQMNGYAVTRAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAEFSVLCRDLYALYPLLIRYVDNNR
AHWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAK
KPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLSFEEKEME
KQRLLYQQARLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGN
ADVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGEK
VMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYL
LRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPC
TGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDM
VVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVG
SEAFQDYVTDPRGLISKKDFQKAAAAAAEFANRFQEPARDIGFNVAVLLT
NLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEIS
ETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEEVQR
VKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPVYYFLEESTGYM
EPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYIT
EQPVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAEGLLT
WLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDI
AMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKS
EDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVF
DITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGSD
YFDTTPHRFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQE
RCWDFFPAGDCFRKQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6x34 Chain H Residue 5101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6x34 Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
Resolution4.7 Å
Binding residue
(original residue number in PDB)		C4959 I4961 H4976 H4981
Binding residue
(residue number reindexed from 1)		C3645 I3647 H3662 H3667
Annotation score1
Gene Ontology
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UnboundLocalError		Python 3.6.8: /usr/bin/python3
Sun Dec 1 16:58:42 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()
   1435     title=pdb2title(pdbid)
   1436     if bs.startswith("BS"):
=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)
   1438     else:
   1439         if lig3:
pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '6x34', asym_id = 'H', bs = 'BS01', title = 'Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.'
 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='6x34', asym_id='H', bs='BS01', title='Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.')
   1295         display_ec(ec,csaOrig,csaRenu)
   1296     if go:
=> 1297         display_go(go,uniprot,pdbid,asym_id)
   1298     return pubmed,uniprot
   1299 
global display_go = <function display_go>, go = '0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6x34', asym_id = 'H'
 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6x34', asym_id='H')
    480         '''.replace("$namespace_link",namespace_link
    481           ).replace("$namespace",namespace
=>  482           ).replace("$uniprot",u
    483         ))
    484         for l,(term,name) in enumerate(go2aspect[Aspect]):
u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>